Doctor en Ciencias Biomédicas, Universidad de Chile, 2004, Chile
(562)29786438
Independencia 1027, pabellon B, primer piso.
Líneas de Investigación
Regulación de Canales Iónicos
Fisiopatología Cardiovascular
Publicaciones Recientes
1.- Moreno C, Hermosilla T, Morales D, Encina M, Torres-Díaz L, Díaz P, Sarmiento D, Simon F, Varela D. 2015. ”Cavβ2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes”. Pflugers Arch. ISSN: 1432-2013 IF: 4.101.
2.- Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, Trimmer JS, Cerda O. 2015. “TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility”. PLoSOne. ISSN: 1932-6203. IF: 3.534
3.- Echeverría C, Montorfano I, Cabello-Verrugio C, Armisén R, Varela D, Simon F. 2015. “Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway”. Journal of Hypertension. ISSN: 0263-6352. IF: 4.72.
4.- Cerda O, Cáceres M, Park KS, Leiva-Salcedo E, Romero A, Varela D, Trimmer JS, Stutzin A. 2015. “Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca(2+)-activated non-selective cation channel TRPM4”. PflugersArch. ISSN: 1432-2013 IF: 4.101.
5.- Flynn R, Chapman K, Iftinca M, Aboushousha R, Varela D, Altier C. 2014. “Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity”. The Journal of Biological Chemistry. ISSN: 0021-9258. IF: 4.6
6.- Echeverría C, Montorfano I, Hermosilla T, Armisén R, Velásquez LA, Cabello-Verrugio C, Varela D, Simon F. 2014. “Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity” PLoSOne. ISSN: 1932-6203. IF: 3.534.
7.- Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F. 2014. “Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel” Microvascular Research ISSN: 1095-9319. IF: 2.126
8.- Simon, F; Varela, D; Cabello-Verrugio, C. 2014. “Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans” CELLULAR SIGNALLING ISSN: 0898-6568. IF: 4.315
9.- Becerra A, Echeverría C, Varela D, Sarmiento D, Armisén R, Nuñez-Villena F, Montecinos M, Simon F. 2011. “Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death”. Cardiovascular Research. ISSN: 0008-6363 IF: 5.940
10.- Nunez-Villena, F , Becerra, A , Echeverria, C. 2011. “Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death”. ANTIOXIDANTS & REDOX SIGNALING. ISSN: 1523-0864 IF: 7.407