Profesor Asociado
Departamento de Pediatría
Facultad de Medicina
Universidad de Chile
Hospital Dr. Luis Calvo Mackenna
Publicaciones Recientes
Farfán M*, Piemonte P, Labra Y, Henríquez J, Candía E, Torres JP. 2016. “Filmarray GI TM panel for detection of enteric pathogens in stool samples: preliminary experience” Rev Chilena Infectol. Feb;33(1):89-91
Conca N, Santolaya ME, Farfan MJ, Cofré F, Vergara A, Salazar L, Torres JP. 2016. “Etiologic diagnosis in meningitis and encephalitis molecular biology techniques”. Rev Chil Pediatr. Jan-Feb;87(1):24-30.
Moraes CT, Polatto JM, Rossato SS, Izquierdo M, Munhoz DD, Martins FH, Pimenta DC, Farfan MJ, Elias WP, Barbosa ÂS, Piazza RM. 2015. “Flagellin and GroEL mediates in vitro binding of an atypical enteropathogenic Escherichia coli to cellular fibronectin” BMC Microbiol. 2015 Dec 18;15:278.
Vergara AF, Vidal RM, Torres AG, Farfan MJ*. 2015. “Long polar fimbriae participates in the induction of neutrophils transepithelial migration across intestinal cells infected with enterohemorrhagic E. coli O157:H7”. Front Cell Infect Microbiol. Jan 8;4:185
Torres JP, Farfan MJ, Izquierdo G, Piemonte P, Henriquez J, O’Ryan ML. 2015. “Enterovirus D68 infection, Chile, Spring 2014”. Emerg Infect Dis. 2015 Apr;21(4):728-9
Gutiérrez D, Pardo M, Montero D, Oñate A, Farfán MJ, Ruiz-Pérez F, Del Canto F, Vidal R.2015. ” TleA, a Tsh-like autotransporter identified in a human enterotoxigenic Escherichia coli strain”. Infect Immun. 2015 May;83(5):1893-903
Izquierdo M, Navarro-Garcia F, Nava-Acosta R, Nataro JP, Ruiz-Perez F, Farfan MJ*. 2014. “Identification of Cell Surface-exposed Proteins Involved in the Fimbria-mediated adherence of Enteroaggregative Escherichia coli to Intestinal Cells”. Infect Immun. Apr;82(4):1719-1724
Izquierdo M, Alvestegui A, Nataro JP, Ruiz-Perez F, Farfan MJ*.2014. “Participation of integrin α5β1 in the fibronectin-mediated adherence of enteroaggregative Escherichia coli to intestinal cells” Biomed Res Int.781246.
Farfan MJ*, Carolina Salas, Cristina Canales, Felipe Silva, Milena Villarroel, Katherine Kopp, Juan P Torres2, María E Santolaya and Jorge Morales (2014) “Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia” BMC Cancer 2014, 14:299
Santolaya ME, Álvarez A, Avilés C, Becker A, Venegas M., Salgado C., Topelberg S, Tordecilla J, Varas M., Villarroel M., Viviani T, Zubieta M., Maza V., Vergara A. Farfán M.J.. Torres J P. (2013).” Prospective Validation of a Risk Prediction Model for Severe Sepsis in Children With Cancer and High-risk Febrile Neutropenia” Pediatr Infect Dis J. Dec;32(12):1318-23
Proyectos Vigentes
2012-2020 Components of the microbiota associated to Diarrheogenic E. coli infection promotes fimbrial-mediated adherence and inflammation induction of Enteroaggregative and ShigaToxin-producing E. coli to intestinal cell models. FONDECYT Nº 1160426, Principal Investigator
2012-2020 Genetic and systematic biomarkers associated with severity of invasive fungal infections in children with cancer, fever and neutropenia: a new insight. Fondecyt N° 1161662, Co-investigador
2012-2020 Characterizing new genetic markers encoded within an undescribed locus of adherence and autoaggregation (LAA) present in Shiga toxin producing E.coli strains clinically relevant. Fondecyt N° 1161161, Co-investigador
2013-2016 Clinical severity and specific gene expression profile in respiratory viral infection in children with cancer, fever and neutropenia: a step forward. Fondecyt N° 11309011, Co-investigador
2012-2016 Association of fibronectin with the secretion of pro-inflammatory cytokines by intestinal cells infected with diarrheagenic E. coli”. FONDECYT Nº 1120809, Principal Investigator
2012-2016 Towards a more rational approach in the comprehensive managment of the child with cancer, fever and neutropenia: Filling the gaps. Fondecyt N° 1120800, Co-investigador