MD Sci PhD (MH-M), Laboratory (main field: Neuropharmacology&Neurochemistry)
Programme of Molecular & Clinical Pharmacology, ICBM, Medical Faculty, University of Chile. Av. Independencia 1027, Block I, 2ndfloor, Independencia, Santiago, Chile.
PO Box 70.000, Santiago 7
Phone: +56-2-9786050
Fax: +56-2-7372783
Cel: +56-09-95348911
Keywords: Neurochemistry, neuropharmacology, histochemistry, neurotransmission, perinatal asphyxia
Research Line
Plasticity of the CNS following metabolic insult occurring at birth; implication for neurodevelopment and psychiatric disorders with delayed onset. The focus is on basal ganglia and limbic pathways investigated with neurochemical, neuropharmacological, histochemical and molecular biology methodologies, in vivo and in vitro.
The laboratory is well funded by national (FONDECYT (1080447; 1030521; 1000626, 11070192; 1095021; 110263; BNIP09-015-F) and international (CONICYT/DAAD No1378-090529; 186-10-2006) grants, and it is inserted in a well established international network, including laboratories in Germany (PJ Gebicke, Mannheim), Sweden (T Hökfelt, Stockholm), Italy (M Morelli, Cagliari), Canada (RA Tasker, Charlottetown, PEI) and Chile (Y Israel, Santiago). MH-M is Associated Editor of several international journals, Including Neurotoxicity Research (Springer), Amino Acids and Proteins (Springer), Journal of Amino Acids.
Senior scientists associated to the lab: Assoc. Professor Paola Morales, PhD, MSci; Assoc. Professor Diego Bustamante, MSci; Mario Rivera, PhD (FONDECYT postdoc).
MH-M coordinates several accredited graduate courses including Advance Course in Clinical & Molecular Pharmacology (12 credits) (August-December), Diploma in Neuropsychopharmacology (12 credits) (August-January).
MH-M has published more than 150 papers cited in PUBMed.
Recent papers
Karahanian E, Rivera-Meza M, Tampier L, Quintanilla ME, Herrera-Marschitz M, Israel Y. 2015. “Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental rea of rats”. Addict Biol 20: 336-344. ISSN: 1369-1600. IF: 5.359
Herrera-Marschitz M, Neira-Pena T, Rojas-Mancilla E, Morales P, Bustamante D, Leyton L, Gebicke-Haerter P. 2015. “Short- and long-term consequences of perinatal asphyxia: looking for neuroprotective strategies”. Adv Neurobiol 10: 169-198. ISSN: 0091-3952. IF: 1.054
Neira Pena T, Rojas-Mancilla E, Munoz-Vio V, Gutierrez-Hernandez M, Bustamante D, Morales P, Hermoso MA, Gebicke-Haerter P, Herrera-Marschitz M. 2015. “Perinatal asphyxia leads to PARP-1 overactivity, p65 translocation, IL-1B and TNF-a overexpression and apoptotic-like cell death in mesencephalon of neonatal rats: prevention by systemic neonatal nicotinamide administration”. Neurotox Res 27: 453-465. ISSN: 1029-8428. IF: 3.538.
SellmannC, Villarin Pildain L, Schmitt A, leonardi-Essmann F, Durrenberger PF, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Gruber O, Herrera-Marschitz M, Reunolds R, Falkai P, Gebicke-Haerter PJ, Matthaus F. 2014. “Gene expression in superior temporal cortex of schizophrenia patients”, Eur Arch Psychiatry Clin Neurosci 264: 297-309. ISSN: 0940-1334. IF: 3.525
Israel, Y, Quintanilla, ME, Karahanian, E. 2015. “The «First Hit» Toward Alcohol Reinforcement: Role of Ethanol Metabolites”. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. ISSN: 1530-0277. IF: 3205
Sellmann, L. Villarín Pildaín, A. Schmitt, F. Leonardi-Essmann, P. F. Durrenberger, R. Spanagel, T. Arzberger, H. Kretzschmar, M. Zink, O. Gruber, M. Herrera-Marschitz, R. Reynolds, P. Falkai, P. J. Gebicke-Haerter, F. Matthäu. 2014. “Gene expression in superior temporal cortex of schizophrenia patients”. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. ISSN: 0940-1334. IF: 3.525
Rivera-Meza, M, Quintanilla, ME, Bustamante, D. 2014. “Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats”. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. ISSN: 1530-0277. IF: 3205
Herrera-Marschitz, M, Neira-Pena, T, Rojas-Mancilla, E. 2014. “Perinatal asphyxia: CNS development and deficits with delayed onset”. FRONTIERS IN NEUROSCIENCE. ISSN: 1662-453X. IF: 3.66
Quintanilla, ME, Rivera-Meza, M, Berrios-Carcamo, P. 2014. “SALSOLINOL, FREE OF ISOSALSOLINOL, EXERTS ETHANOL- LIKE MOTIVATIONAL/SENSITIZATION EFFECTS LEADING TO INCREASES IN ETHANOL INTAKE”. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. ISSN: 1530-0277. IF: 3205
Quintanilla, ME, Rivera-Meza, M, Berrios-Carcamo, PA. 2014. “Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake”. ALCOHOL. ISSN: 0741-8329. IF: 2.006