Doctor en Ciencias Biomédicas, 2003

Universidad de Chile

Biología Celular y Molecular

Laboratorio: Laboratorio de Transformación Celular, Programa de Biología Celular y Molecular, ICBM (ORCID: 0000-0003-1678-2708)

Área de investigación: Bioquímica, Biología Molecular, Biología Celular

Líneas de Investigación:

  1. Effect of interaction of the N-terminal domain of ECE-1c with 14-3-3 proteins in cancer cells
  2. Effect of 14-3-3 binding on ECE-1c stability and cancer stem cell-related signaling
  3. Blockage of phospho-ECE-1c:14-3-3 interaction and its effects in vitro and in vivo on aggressiveness of cancer cells

Resumen investigación y financiamiento:

Our main research interest is the study of the molecular and cellular mechanisms regulated by the protein kinase CK2 which promote tumorigenesis and metastasis of colorectal and other cancers. Our group has reported the CK2-dependent up-regulation of several cell signaling pathways, including the canonical Wnt/β-catenin, PI3k/Akt/mTORC1, and currently the Endothelin-1 axis. Our more recent novel findings include the methuosis-like death of colorectal cancer cells induced by the specific CK2 inhibitor silmitasertib, as well as the role of the endothelin-converting enzyme-1c (ECE1c) in acquisition of malignant traits in colorectal, glioblastoma and lung cancer cells.


Publicaciones Recientes

  1. Niechi I., Erices J.I., Carrillo-Beltrán D., Uribe-Ojeda A., Torres A., Rocha J-D., Uribe D., Toro M.A., Villalobos-Nova K., Gaete-Ramírez B., Mingo G., Owen G.I., Varas-Godoy M., Jara L., Aguayo F., Burzio V.A., Quezada C.*, Tapia J.C.* “Cancer stem cell and aggressiveness traits are promoted by stable endothelin-converting enzyme-1c in glioblastoma cells” Cells (2023) Feb 3;12(3):506.
  2. Landeros N., Gonzalez‐Hormazabal P., Pérez‐Moreno P., Tapia J.C.*, Jara L.* “A single variant in pri‐miRNA‐155 associated with susceptibility to hereditary breast cancer promotes aggressiveness in breast cancer cells” International Journal of Molecular Sciences (2022) 23: 15418.
  3. Morales-Pison S., Jara L., Carrasco V., Gutiérrez-Vera C., Reyes J.M., Gonzalez-Hormazabal P., Carreño L.J., Contreras H.R., Tapia J.C.* “Genetic variation in microRNA-423 promotes proliferation, migration, invasion, and chemoresistance in breast cancer cells” International Journal of Molecular Sciences (2022) 23:380.
  4. Pérez-Moreno P., Quezada-Meza C., Chavez-Almarza C., Niechi I., Silva-Pavez E., Trigo-Hidalgo C., Aguayo F., Jara L., Cáceres-Verschae A., Varas-Godoy M., Diaz V.M., Garcia De Herreros A., Burzio V.A., Tapia J.C.* “Phosphorylation of endothelin-converting enzyme-1c at serines 18 and 20 by CK2 promotes aggressiveness traits in colorectal cancer cells” Frontiers in Oncology (2020) Jul 30;10:1004.
  5. Carrillo-Beltrán D., Muñoz J.P., Guerrero-Vasquez N., Blanco R., León O., De Souza Lino V., Tapia J.C., Maldonado E., Dubois-Camacho K., Hermoso M., Corvalán A.H., Calaf G.M., Boccardo E., Aguayo F.* “Human Papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-κB activation in oral cancer cells” Cancers (2020) 15;12(7):E1904.
  6. Silva-Pavez E., Tapia J.C.* “Protein kinase CK2 in cancer energetics” Frontiers in Oncology (2020) Jun 18;10:893.
  7. Fernandez-Moya A., Morales S., Arancibia T., Gonzalez-Hormazabal P., Tapia J.C., Godoy-Herrera R., Reyes J.M., Gomez F., Waugh E., Jara L.* “Germline variants in driver genes of breast cancer and their association with familial and early-onset breast cancer risk in a South American population” Cancers (2020) Jan 20;12(1):249.
  8. Pérez-Moreno P., Indo S., Niechi I., Huerta H., Cabello P., Jara L., Aguayo F., Varas-Godoy M., Burzio V.A., Tapia J.C.* “Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells” Molecular Oncology (2020) 14(2): 347-362.
  9. Silva-Pavez E., Villar P., Trigo C., Caamaño E., Niechi I., Pérez P., Muñoz J.P., Aguayo F., Burzio V.A., Varas-Godoy M., Castro A.F., Colombo M.I., Tapia J.C.* “CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells” Cell Death & Disease (2019) Jan 25;10(2):73-86.
  10. Tapia J.C.*, Niechi I. “Endothelin-converting enzyme-1 in cancer aggressiveness” Cancer Letters (2019) 452: 152-157.