Dentist (DDs), Universidad de Chile, Chile

PhD in Dental Sciences, Faculty of Medicine, University of Helsinki, 2012, Finland

Research Lines

Etiology, pathogenesis and systemic complications of oral diseases.

Identification of biomarkers in oral fluids.


  1. Bologna-Molina R, Pereira-Prado V, Tapia G, Soria S, Hernandez M, Gónzalez-Gónzalez R, Molina Frechero N, Mikami T, 2017, Expression of hMLH1, hMSH2 and Ki-67 proteins in ameloblastomas and tooth germs. Accepted in Medicina Oral Patologia Oral Cirugia Bucal, Dec 6. ISSN 1698-6946
  2. Hernández-Caldera A, Vernal R, Paredes R, Veloso-Matta P, Astorga J, Hernández M, 2017, Human Periodontal Ligament Fibroblasts synthesize C-Reactive Protein and Th-Related Cytokines in response to Interleukin (IL)-6 trans-signaling. Accepted in Int. Endodont. J. ISSN1365-2591
  3. Nieminen MT, Listyarifah D, Hagström J, Haglund C, Grenier D, Nordström D, Uitto VJ, Hernandez M, Yucel-Lindberg T, Tervahartiala T, Ainola M, Sorsa T, Treponemadenticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation. Br J Cancer. 2017 Nov 16. doi: 10.1038/bjc.2017.409. ISSN 0007-0920. IF 6.176
  4. Sorsa T, Gieselmann D, Arweiler NB, Hernández M,2017, A quantitative point-of-care test for periodontal and dental peri-implant diseases.Nat Rev Dis Primers. Sep 14;3:17069.ISSN2056-676XIF 6.389
  5. Hernández-Ríos P, Pussinen PJ, Vernal R, Hernández M,2017, Oxidative Stress in the Local and Systemic Events of Apical Periodontitis. Front. Physiol., Nov 8; 869. ISSN 1664-042X
  6. Cavalla F, Hernández-Ríos P, Sorsa T, Biguetti C, Hernández M,2017, Matrix Metalloproteinases as Regulators of Periodontal Inflammation. Int J Mol Sci. Feb 17;18(2). ISSN 1422-0067
  7. Salinas-Muñoz M, Garrido-Flores M, Baeza M, Huamán-Chipana P, García-Sesnich J, Bologna R, Vernal R, Hernández M. Bone resorptive activity in Symptomatic and Asymptomatic Apical Lesions of Endodontic Origin. 2017 Nov;21(8):2613-2618. ISSN 2283-2290
  8. Liljestrand JM, Mäntylä P, Paju S, Buhlin K, Kopra KA, Persson GR, Hernandez M, Nieminen MS, Sinisalo J, Tjäderhane L, Pussinen PJ. “Association of Endodontic Lesions with Coronary Artery Disease”. J Dent Res. 2016. 95(12): ISSN: 0022-0345.
  9. Morales A, Carvajal P, Silva N, Hernandez M, Godoy C, Rodriguez G, Cabello R, Garcia-Sesnich J, Hoare A, Diaz PI, Gamonal J.Clinical effects of lactobacillus rhamnosus in non-surgical treatment of chronic periodontitis: A randomized placebo-controlled trial with 1-year follow-up”. J Periodontol. 2016. 87(8):944-52. ISSN: 0022-3492.
  10. Baeza M, Garrido M, Hernández-Ríos P, Dezerega A, García-Sesnich J, Strauss F, Aitken JP, Lesaffre E, Vanbelle S, Gamonal J, Brignardello-Petersen R, Tervahartiala T, Sorsa T, Hernández M. “Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid. J ClinPeriodontol. 2016. 43(1):34-45. ISSN: 0303-6979.
  11. Martínez C, Hernández M, Martínez B, Adorno, D. “Frecuencia de displasia epitelial y carcinoma escamoso en mucosa oral y orofaríngea en Chile, entre los años 1990 y 2009”. RevMed Chile 2016. 144(2):169-74. ISSN 0034-9887.
  12. Sorsa T, Gursoy UK, Nwhator S, Hernandez M, Tervahartiala T, Leppilahti J, Gursoy M, Könönen E, Emingil G, Pussinen PJ, Mäntylä P. “Analysis of matrixmetalloproteinases in gingival crevicular fluid (GCF), mouthrinse and saliva formonitoring periodontal diseases”. Periodontol 2000. 2016. 70(1):142-63. ISSN: 0906-6713.
  13. Silva N., Abusleme L., Bravo D., Dutzan N., Garcia-Sesnich J., Vernal R., Hernández M., Gamonal J. “Host Response Mechanisms in Periodontal Diseases”. J Appl Oral Sci. 2015. 23(3):329-55. ISSN: 1678-7757.
  14. Cavalla F, Osorio C, Paredes R, Valenzuela M.A, García-Sesnic J, Sorsa T, Tervahartiala T, Hernández M. “Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF and in hydrogen peroxide-stimulated human periodontal ligament fibroblasts”. Cytokine. 2015. 73:114-21. ISSN: 1043-1066.
  15. Osorio C, Cavalla F, Paula-Lima A, Díaz-Araya G, Vernal R, Ahumada P, Gamonal J, Hernández M. “H2O2 activates matrix metalloproteinases through nuclear factor kappa B pathway and Ca2+ signals in human periodontal fibroblasts”. J Periodont Res. 2015. 50(6):798-806. ISSN: 0022-3484.
  16. Garrido M, Dezerega A, Bordagaray MJ, Reyes M, Vernal R, Melgar-Rodríguez S, Ciuchi P, Paredes R, García-Sesnich J, Ahumada-Montalva P, Hernández M. 2015“C Reactive Protein synthesis is induced in apical lesions of endodontic origin in association with interleukin-6”. J Endod. Apr;41(4):464-9ISSN 1878-3554
  17. Åström P, Pirilä E, Lithovius R, Heikkola H, Korpi JT, Hernández M, Sorsa T, Salo T. “Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro”. Exp Cell Res. 2014. Oct 15;328(1):217-27. ISSN: 0014-4827.
  18. Nieminen MT, Hernandez M, Novak-Frazer L, Kuula H, Ramage G, Bowyer P, Warn P, Sorsa T, Rautemaa R. “D,L-2-hydroxyisocaproic acid (HICA) attenuates inflammatory response in Candida albicans biofilm murine model”. Clin Vaccine Immunol. 2014. 21(9):1240-5. ISSN: 1556-6811.
  19. Kallio KA, Marchesani M, Vlachopoulou E, Mäntylä P, Paju S, Buhlin K, Suominen AL, Contreras J, Knuuttila M, Hernandez M, Huumonen S, Nieminen MS, Perola M, Sinisalo J, Lokki ML, Pussinen PJ. “Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis”. InfectImmun. 2014. 82(5):1939-48. ISSN: 0019-9567.
  20. Leppilahti JM, Hernández-Ríos P, Gamonal J, Tervahartiala T, Brignardello-Petersen R, Mantyla P, Sorsa T, Hernández M. “MMPs and myeloperoxidase in GCF providesite-specificdiagnosticvalueforchronic periodontitis”. J ClinPeriodontol. 2014. 41(4):348-56. ISSN: 0303-6979.
  21. Díaz-Zúñiga J, Yáñez JP, Alvarez C, Melgar-Rodríguez S, Hernández M, Sanz M, Vernal R. “Serotype-dependent response of human dendritic cells stimulated with Aggregatibacteractinomycetemcomitans”. J ClinPeriodontol. 2014. 41(3):242-51. ISSN: 0303-6979.