mchiong@uchile.cl or mchiong@ciq.uchile
http://www.cellsignalinglab.cl/
1986 Biochemist. University of Chile, Santiago, Chile
2009 PhD in Pharmacology. University of Chile, Santiago, Chile
RESEARCH LINES
- Metabolism in cardiovascular diseases.
- Signal transduction in cardiovascular system.
- Cell death mechanism.
PAPERS
Parra V, Verdejo HE, Iglewski M, Campo AD, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes. 2014;63:75-88.
Del Campo A, Parra V, Vásquez-Trincado C, Gutiérrez T, Morales PE, López-Crisosto C, Bravo-Sagua R, Navarro-Marquez MF, Verdejo HE, Contreras-Ferrat A, Troncoso R, Chiong M, Lavandero S. Mitochondrial fragmentation impairs insulin-dependent glucose uptake by Akt activity through mitochondrial Ca2+ uptake. Am J Physiol Endocrinol Metab. 2014;306:E1-E13.
Carrasco L, Cea P, Rocco P, Peña-Oyarzún D, Rivera-Mejias P, Sotomayor-Flores C, Quiroga C, Criollo A, Ibarra C, Chiong M, Lavandero S. Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1. J Cell Biochem. 2014;115:712-20.
Winter JL, Castro PF, Quintana JC, Altamirano R, Enriquez A, Verdejo HE, Jalil JE, Mellado R, Concepción R, Sepúlveda P, Rossel V, Sepúlveda L, Chiong M, García L, Lavandero S. Effects of trimetazidine in non-ischemic heart failure: A randomized study. J Card Fail. 2014;20:149-54.
Ocaranza MP, Moya J, Barrientos V, Alzamora R, Hevia D, Morales C, Pinto M, Escudero N, García L, Novoa U, Ayala P, Díaz-Araya G, Godoy I, Chiong M, Lavandero S, Jalil JE, Michea L. Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis. J Hypertens. 2014;32:771-83.
Zepeda R, Kuzmicic J, Parra V, Troncoso R, Pennanen C, Riquelme JA, Pedrozo Z, Chiong M, Sánchez G, Lavandero S. Drp1 loss-of-function reduces cardiomyocyte oxygen-dependence protecting the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol. 2014;63:477-87.
Bravo R, Torrealba N, Paredes F, Morales PE, Pennanen C, López-Crisosto C, Troncoso R, Chiong M, Simmen T, Quest AF, Lavandero S. Organelle communication: Signaling crossroads of homeostasis and disease. Int J Biochem Cell Biol. 2014;50C:55-59.
Ocaranza MP, Michea L, Chiong M, Lavandero S, Jalil JE. Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure. J Hypertens. 2014;32:1719-21.
Pennanen C, Parra V, López-Crisosto C, Morales PE, Del Campo A, Gutierrez T, Rivera-Mejías P, Kuzmicic J, Chiong M, Zorzano A, Rothermel BA, Lavandero S. Mitochondrial fission is required for cardiomyocyte hypertrophy via a Ca2+-calcineurin signalling pathway. J Cell Sci. 2014;127:2659-71.
Morales PE, Torres G, Sotomayor-Flores C, Peña-Oyarzún D, Rivera-Mejías P, Paredes F, Chiong M. GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum – mitochondria coupling. Biochem Biophys Res Commun. 2014;446:410-16.
Ocaranza MP, Michea L, Chiong M, Lagos CF, Lavandero S, Jalil JE. Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system. Clin Sci (Lond). 2014;127:549-57.
Kuzmicic J, Parra V, Verdejo HE, López-Crisosto C, Chiong M, García L, Jensen MD, Bernlohr DA, Castro PF, Lavandero S. Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes. Biochem Pharmacol. 2014;91:323-36.
Ocaranza MP, Michea L, Chiong M, Lavandero S, Jalil JE. Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure. J Hypertens. 2014;32:1719-21.
Chiong M, Cartes-Saavedra B, Norambuena-Soto I, Mondaca-Ruff D, Morales PE, García-Miguel M, Mellado R. Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation. Front Cell Dev Biol. 2014;2:72.
Gutiérrez T, Parra V, Troncoso R, Pennanen C, Contreras-Ferrat A, Vasquez-Trincado C, Morales PE, Lopez-Crisosto C, Sotomayor-Flores C, Chiong M, Rothermel BA, Lavandero S. Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes. Cell Commun Signal. 2014;12:68.
Gatica D, Chiong M, Lavandero S, Klionsky DJ. Molecular mechanisms of autophagy in the cardiovascular system. Circ Res. 2015;116:456-67.
Lavandero S, Chiong M, Rothermel BA, Hill JA. Autophagy in cardiovascular biology. J Clin Invest. 2015;125:55-64.
Westermeier F, Bustamante M, Pavez M, García L, Chiong M, Ocaranza MP, Lavandero S. Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9). Pharmacol Res. 2015;101:41-55.
Mendoza-Torres E, Oyarzún A, Mondaca-Ruff D, Azocar A, Castro PF, Jalil JE, Chiong M, Lavandero S, Ocaranza MP. ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension. Ther Adv Cardiovasc Dis. 2015;9:217-37.
Verdejo HE, Becerra E, Zalaquet R, Del Campo A, Garcia L, Troncoso R, Chiong M, Marin A, Castro PF, Lavandero S, Gabrielli L, Corbalán R. Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients. Echocardiography. 2016;33:242-8. doi: 10.1111/echo.13059
Díaz A, Humeres C, González V, Gómez MT, Montt N, Sanchez G, Chiong M, García L. Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death. Biochem Biophys Res Commun. 2015;467:451-7.
Vivar R, Humeres C, Muñoz C, Boza P, Bolivar S, Tapia F, Lavandero S, Chiong M, Diaz-Araya G. FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation. Biochim Biophys Acta. 2016;1863:128-38. doi: 10.1016/j.bbamcr.2015.10.019.
Paredes F, Parra V, Torrealba N, Navarro-Marquez M, Gatica D, Bravo-Sagua R, Troncoso R, Pennanen C, Quiroga C, Chiong M, Caesar C, Taylor WR, Molgó J, San Martin A, Jaimovich E, Lavandero S. HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor. Free Radic Biol Med. 2016;90:206-218.
Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S. BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism. Autophagy. 2016;12:287-96.
Chiong M. Dilucidando el mecanismo de acción de fibratos. Rev Chil Cardiol. 2016; 35:144-146.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Chiong M, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12:1-222.
Torres G, Morales PE, García-Miguel M, Norambuena-Soto I, Cartes-Saavedra B, Vidal-Peña G, Mondaca-Ruff D, Sanhueza-Olivares F, San Martín A, Chiong M. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem Pharmacol. 2016;104:52-61. doi: 10.1016/j.bcp.2016.01.013.
Choi SY, Lee HH, Lee JH, Ye BJ, Yoo EJ, Kang HJ, Jung GW, An SM, Lee-Kwon W, Chiong M, Lavandero S, Kwon HM. TonEBP suppresses IL-10-mediated immunomodulation. Sci Rep. 2016;6:25726.
Pizarro M, Troncoso R, Martínez GJ, Chiong M, Castro PF, Lavandero S. Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity. Toxicology. 2016;370:41-48.
Palacios J, Cifuentes F, Valderrama JA, Benites J, Ríos D, González C, Chiong M, Cartes-Saavedra B, Lafourcade C, Wyneken U, González P, Owen GI, Pardo F, Sobrevia L, Buc Calderon P. Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta. Oxid Med Cell Longev. 2016;2016:3939540.
Gabrielli L, Ocaranza MP, Sitges M, Kanacri A, Saavedra R, Sepulveda P, Sepulveda L, Rossel V, Zagolin M, Verdejo HE, Baraona F, Zalaquett R, Chiong M, Lavandero S, Castro PF. Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension. Echocardiography. 2017;34:53-60.
Norambuena-Soto I, Núñez-Soto C, Sanhueza-Olivares F, Cancino-Arenas N, Mondaca-Ruff D, Vivar R, Díaz-Araya G, Mellado R, Chiong M. Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators. Biosci Trends. 2017;11:154-162. doi: 10.5582/bst.2017.01017.
Lopez-Crisosto C, Pennanen C, Vasquez-Trincado C, Morales PE, Bravo-Sagua R, Quest AFG, Chiong M, Lavandero S. Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology. Nat Rev Cardiol. 2017;14:342-360. doi: 10.1038/nrcardio.2017.23.
Del Campo A, Roldán J, Verdejo HE, Zalaquett R, Becerra E, Navarro-Marquez M, Mellado R, Lavandero S, Corbalán R, García L, Chiong M. Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation. J Cardiol. 2017 Dec;70(6):578-583. doi: 10.1016/j.jjcc.2017.03.011.
Parra V, Bravo-Sagua R, Norambuena-Soto I, Hernández-Fuentes CP, Gómez-Contreras AG, Verdejo HE, Mellado R, Chiong M, Lavandero S, Castro PF. Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells. Biochim Biophys Acta. 2017;1863:2891-2903. doi: 10.1016/j.bbadis.2017.07.018.
Torrealba N, Navarro-Marquez M, Garrido V, Pedrozo Z, Romero D, Eura Y, Villalobos E, Roa JC, Chiong M, Kokame K, Lavandero S. Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation. Sci Rep. 2017 Oct 17;7(1):13402. doi: 10.1038/s41598-017-13797-z.
Córdova-Casanova A, Olmedo I, Riquelme JA, Barrientos G, Sánchez G, Gillette TG, Lavandero S, Chiong M, Donoso P, Pedrozo Z. Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism. Biochim Biophys Acta. 2017;1865:289-296. doi: 10.1016/j.bbamcr.2017.11.001