Claustro Académico

Daniela Macarena Sauma Mahaluf

dsauma@u.uchile.cl

Doctora en Ciencias, mención Biología Molecular, Celular y Neurociencias, Facultad de Ciencias, Universidad de Chile (2008)

Research Line

Memory CD8+ T cell differentiation for cancer immunotherapy

Papers

  • Felipe Flores-Santibáñez, Bárbara Cuadra, Dominique Fernández,Mariana Rosemblatt, Sarah Núñez, Pablo Cruz, Felipe Gálvez-Cancino, J.César Cárdenas, Alvaro Lladser, Mario Rosemblatt, María Rosa Bonoand Daniela Sauma. In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo. Frontiers in Immunology. 9:209. doi: 10.3389/fimmu.2018.00209 (2018).

 

  • Morales J, Barrera-Avalos C, Castro C, Castillo S, Barrientos C, Robles-Planells C, López X, Torres E, Montoya M, Cortez-San Martín M, Riquelme D, Escobar A, Fernández R, Imarai M, Sauma D, Rojo LE, Leiva-Salcedo E, Acuña-Castillo C. Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro. Frontiers in Immunology. 8:1170. doi: 10.3389/fimmu.2017.01170 (2017).

 

  • Daniela Sauma, Natalia Crisóstomo, Camila Fuentes, María Alejandra Gleisner, Yessia Hidalgo, María José Fuenzalida, Mario Rosemblatt&María Rosa Bono. Adoptive transfer of autoimmunesplenicdendriticcells
to lupus-pronemicetriggers a B lymphocyte humoral response. Immunol Res. 65(4):957-968. doi: 10.1007/s12026-017-8936-9 (2017).

 

  • Felipe Gálvez-Cancino, Jonathan Roco, Nicole Rojas-Colonelli, Camila Flores, Paola Murgas, Sebastián Cruz-Gómez, César Oyarce, Manuel Varas-Godoy, Daniela Sauma, AlvaroLladser. A short hairpin RNA-basedadjuvanttargeting NF-κBrepressorIκBα promotesmigration of dermal dendriticcellstodraininglymphnodes and antitumor CTL responses inducedby DNA vaccination. Vaccine. 35(33):4148-4154. doi: 10.1016/j.vaccine.2017.06.041. (2017).

 

  • Maria Rosa Bono, Gabriela Tejon, Felipe Flores-Santibañez, Dominique Fernandez, Mario Rosemblatt, Daniela Sauma. Retinoic Acid as a Modulator of T Cell Immunity. Nutrients, 13;8(6). pii: E349. doi: 10.3390/nu8060349. (2016).

 

  • Dominique Fernández, Felipe Flores-Santibáñez, Jocelyn Neira, Francisco Osorio-Barrios, Gabriela Tejón, Sarah Nuñez, Yessia Hidalgo, Maria Jose Fuenzalida, Daniel Meza, Gonzalo Ureta, Alvaro Lladser, Rodrigo Pacheco, Claudio Acuña-Castillo, Victoria Guixé, Francisco J. Quintana, Maria Rosa Bono, Mario Rosemblatt, Daniela Sauma.Purinergic Signaling as a Regulator of Th17 cell Plasticity. Plos One, 20;11(6):e0157889. doi: 10.1371/journal.pone.0157889. (2016).

 

  • Ruiz P, Maldondado P, Hidalgo Y, Sauma D, Rosemblatt M, and Bono MR. Alloreactive Regulatory T cells Allow the generation of Mixed Chimerism and Transplant Tolerance. Front Immunol. 6: 596 (2015).

 

  • Felipe Flores-Santibáñez, Dominique Fernández, Daniel Meza, Gabriela Tejón, Leonardo Vargas, Lorena Varela-Nallar, Sebastián Arredondo, Victoria Guixé, Mario Rosemblatt, María Rosa Bono, Daniela Sauma. CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells. Immunology, 146(4):582-94 (2015).

 

  • María Rosa Bono, Dominique Fernández, Felipe Flores-Santibáñez, Mario Rosemblatt, Daniela Sauma. CD73 and CD39 ectonucleotidases in T celldifferentiation: beyondimmunosuppression. FEBS Letters. 589 (22): 3454-60 (2015).

 

  • Gabriela Tejón, Valeria Manríquez, Jaime De Calisto, Felipe Flores-Santibáñez, Yessia Hidalgo, Natalia Crisóstomo, Dominique Fernández, Daniela Sauma, J. Rodrigo Mora, María R. Bono, and Mario Rosemblatt.Vitamin A ImpairstheReprogramming of Tregs into IL-17-Producing Cellsduring Intestinal Inflammation. BioMedResearch International 2015:137893. doi: 0.1155/2015/137893(2015).

 

  • Carolina Moore, Gabriela Tejón, Camila Fuentes, Yessia Hidalgo, Maria Rosa Bono, Paula Maldonado, Ricardo Fernandez, Kathryn Wood, Juan Alberto Fierro, Mario Rosemblatt, Daniela Sauma and Andrew Bushell. Alloreactive regulatory T cellsgeneratedwithretinoicacidpreventskinallograftrejection. Eur J Immunol. 45: 452-463 (2015).

 

  • Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan JoseSaez, Sarah Nuñez, Mario Rosemblatt and Maria Rosa Bono. TransplantTolerance: New Insights and Strategiesfor Long-TermAllograftAcceptance. Clinical and DevelopmentalImmunology, 1-15 (2013).

 

  • Maria Alejandra Gleisner, Paz Reyes, Jennifer Alfaro, Paola Solanes, ValeskaSimon, Natalia Crisostomo, Daniela Sauma, Mario Rosemblatt, Maria Rosa Bono. Dendritic and stromalcellsfromthespleen of lupicmicepresentphenotypic and functional abnormalities. Molecular Immunology. 54, 423-434 (2013).

 

  • Sarah Núñez, Juan José Sáez, Dominique Fernández, Felipe Flores-Santibañez, Karla Alvarez, Gabriela Tejón, Paulina Ruíz, Paula Maldonado, Yessia Hidalgo, Valeria Manríquez, María Rosa Bono, Mario Rosemblatt, Daniela Sauma. Type 17 T helpercellscontributeto anti-tumor immunity and promotetherecruitment of Th1 cellstothe tumor. Immunology. 139, 61-71 (2013).