Ph.D, en bioquímica, Universidad de Estocolmo, Suecia, 1989
Líneas de Investigación
Mecanismos de neurodegeneración en enfermedad de Parkinson
Publicaciones Recientes
Segura-Aguilar J, Paris I, Muñoz P, Ferrari E, Zecca L, Zucca FA.J 2014. “Protective and toxic roles of dopamine in Parkinson’s disease”. Neurochem. 2014 Jun;129(6):898-915. doi: 10.1111/jnc.12686. Epub 2014 Mar 18. ISSN: 1471-4159. IF:4.281.
Huenchuguala S, Muñoz P, Zavala P, Villa M, Cuevas C, Ahumada U, Graumann R, Nore BF, Couve E, Mannervik B, Paris I, Segura-Aguilar J.. 2014. “Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction”. Autophagy. 2014 Apr;10(4):618-30. doi: 10.4161/auto.27720. Epub. ISSN: 1554-8635. IF: 11.743
Villa M, Muñoz P, Ahumada-Castro U, Paris I, Jiménez A, Martínez I, Sevilla F, Segura-Aguilar J. 2013. “One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity”. Neurotox Res. 2013 Jul;24(1):94-101. doi: 10.1007/s12640-013-9382-7. Epub 2013 Feb 6. ISSN: 1029-8428. IF: 3.538.
Klionsky DJ, Abdalla FC, et al., Segura-Aguilar J, et al., 2012. “Guidelines for the use and interpretation of assays for monitoring autophagy”. Autophagy. 2012 Apr;8(4):445-544. ISSN: 1554-8635. IF: 11.743
Muñoz P, Huenchuguala S, Paris I, Segura-Aguilar J. 2012. “Dopamine oxidation and autophagy”. Parkinsons Dis. 2012; 2012:920953. doi: 10.1155/2012/920953. Epub 2012 Aug 26.PMID: 22966478 [PubMed]. ISSN: 1877-7171. IF: 1.91
Kumar KR, Weissbach A, Heldmann M, Kasten M, Tunc S, Sue CM, Svetel M, Kostić VS, Segura-Aguilar J, Ramirez A, Simon DK, Vieregge P, Münte TF, Hagenah J, Klein C, Lohmann K. 2012. “Frequency of the D620N mutation in VPS35 in Parkinson disease”. Arch Neurol. 2012 Oct;69(10):1360-4. ISSN: 0003-9942. IF:7.419
Muñoz P, Huenchuguala S, Paris I, Cuevas C, Villa M, Caviedes P, Segura-Aguilar J, Tizabi Y. 2012. “Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson’s disease”..Neurotox Res. 2012 Aug;22(2):177-80. doi: 10.1007/s12640-012-9326-7. Epub 2012 Apr 12. Erratum in: Neurotox Res. 2012 Oct;22(3):249. ISSN: 1029-8428. IF: 3.538.
Muñoz P, Paris I, Sanders LH, Greenamyre JT, Segura-Aguilar J. 2012. “Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity”. Biochim Biophys Acta. 2012 Jul;1822(7):1125-36. doi: 10.1016/j.bbadis.2012.03.010. Epub 2012 Mar 27. ISSN: 0304-4165. IF: 4.381
Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C. 2012. “Targeting the UPR transcription factor XBP1 protects against Huntington’s disease through the regulation of FoxO1 and autophagy”. Hum Mol Genet. 2012 May 15;21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14. ISSN: 0964-6906. IF: 6.393
Aguirre P, Urrutia P, Tapia V, Villa M, Paris I, Segura-Aguilar J, Núñez MT 2012. “The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1”.. Biometals. 2012 Aug;25(4):795-803. doi: 10.1007/s10534-012-9525- ISSN: 0966-0844. IF: 2.503