Doctor en Ciencias Biomédicas, 2003

Universidad de Chile

Biología Celular y Molecular

Líneas de Investigación

Biología celular y molecular del cáncer de colon.

Papel de la proteína CK2 en cánceres sólidos.

Nuevos blancos moleculares para diagnóstico, pronóstico y terapia de cáncer de colon.

Publicaciones Recientes

1.- Niechi I., Silva E., Cabello P., Tapia JC. 2015 “Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability” Oncotarget. ISSN: 1949-2553 .IF: 6.630.


2.- Rivas S, Armisén R, Rojas D, Maldonado E, Huerta H, Tapia JC, Espinoza J, Colombo A, Michea L, Hayman MJ, Marcelain K. 2015. “The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A” JOURNAL OF CELLULAR BIOCHEMISTRY. ISSN: 1097-4644 .IF: 3.368.


3.- Campos T, Ziehe J, Palma M, Escobar D, Tapia JC, Pincheira R, Castro AF.,. 2014. “Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy” MOLECULAR CARCINOGENESIS. ISSN: 1098-2744. IF: 4.770.


4.- Leyton Y, Gonzalez-Hormazabal P, Blanco R, Bravo T, Fernandez-Ramires R, Morales S, Landeros N, Reyes JM, Peralta O, Tapia JC, Gomez F, Waugh E, Ibañez G, Pakomio J, Grau G, Jara L.., 2014 “Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population” BMC CANCER. ISSN: 1471-2407 IF: 3.319.


5.- Fernández JG, Rodríguez DA, Valenzuela M, Calderon C, Urzúa U, Munroe D, Rosas C, Lemus D, Díaz N, Wright MC, Leyton L, Tapia JC, Quest AF. 2014. “Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription” MOLECULAR CANCER. ISSN: 1476-4598. IF: 5.397.


6.- Lucero C., Vega O., Osorio M., 2013. “The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines” JOURNAL OF CELLULAR PHYSIOLOGY. ISSN: 1097-4652. IF: 3.839.


7.- Mosquera, J , Armisen, R , Zhao, HL. 2011. “Identification of Ski as a target for Aurora A kinase”. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. ISSN:0006-219X. IF: 2.281.


8.- Ponce DP1, Maturana JL, Cabello P, Yefi R, Niechi I, Silva E, Armisen R, Galindo M, Antonelli M, Tapia JC. 2011. “Phosphorylation of AKT/PKB by CK2 Is Necessary for the AKT-Dependent Up-Regulation of beta-Catenin Transcriptional Activity”. JOURNAL OF CELLULAR PHYSIOLOGY. ISSN: 1097-4652 IF: 3.839.


9.- Armisén R, Marcelain K, Simon F, Tapia JC, Toro J, Quest AF, Stutzin A. 2011. “TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway”. JOURNAL OF CELLULAR PHYSIOLOGY. ISSN: 1097-4652 IF: 3.839.


10.- Ponce DP1, Yefi R, Cabello P, Maturana JL, Niechi I, Silva E, Galindo M, Antonelli M, Marcelain K, Armisen R, Tapia JC. 2011. “CK2 functionally interacts with AKT/PKB to promote the beta-catenin-dependent expression of survivin and enhance cell survival” MOLECULAR AND CELLULAR BIOCHEMISTRY. ISSN: 0300-8177. IF: 2.338