Profesor Asociado (Programa Farmacología Molecular & Clínica, ICBM, Facultad de Medicina, Universidad de Chile).
Línea de Investigación
Toxicología y Farmacocinética (Efectos tóxicos del vanadio en hígado; Laboratorio Dr. KJ. Nette, Instituto de Farmacología & Toxicología, Philipps Universität. Marburg, Alemania Federal).
Publicaciones
Ezquer F*, Quintanilla ME*, Morales P, Ezquer M, Lespay-Rebolledo C, Herrera-Marschitz M, Israel Y (2019) Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats. Addict Biol. 2019 Jan;24(1):17-27. doi: 10.1111/adb.12572. *First autor.ISI = 5.578
Quintanilla ME*, Morales P, Ezquer F, Ezquer M, Herrera-Marschitz M, Israel Y (2018) Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine. Alcohol Clin Exp Res 2018. 42(10):1988-1999. doi: 10.1111/acer.13842. Epub 2018 Aug 13.* First autor. ISI = 3.183
Ezquer F*, Quintanilla ME*, Morales P, Santapau D, Ezquer M, Kogan MJ, Salas-Huenuleo E, Herrera-Marschitz M, Israel Y (2018) Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. Addict Biol. 2018 Sep 21. doi: 10.1111/adb.12675.*First autor. ISI = 5.578
Mattalloni MS, Albrecht PA, Salinas-Luypaert C, Deza-Ponzio R, Quintanilla ME, Herrera-Marschitz M, Cancela LM, Rivera-Meza M, Virgolini MB (2018) Silencing brain catalase expression reduces ethanol intake in developmentally-lead-exposed rats. Neurotoxicology. 2018 Oct 30;70:180-186. doi: 10.1016/j.neuro.2018.10.010. ISI = 3.076
Rivera-Meza M, Vásquez D, Quintanilla ME, Lagos D, Rojas B, Herrera-Marschitz M, Israel Y (2018) Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?. Neuropharmacology. 2018 Dec 4;146:175-183. doi: 10.1016/j.neuropharm.2018.12.001. ISI = 4.249
Quiroz G, Guerra-Díaz N, Iturriaga-Vásquez P, Rivera-Meza M, Quintanilla ME, Sotomayor-Zárate R (2018) Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. Behav Brain Res. 2018 Apr 25. pii: S0166-4328(18)30139-6. ISI= 3.48 doi: 10.1016/j.bbr.2018.04.038
Ezquer F, Morales P, Quintanilla ME, Santapau D, Lespay-Rebolledo C, Ezquer M, Herrera-Marschitz M, Israel Y (2018) Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking. Scientific Report. Mar 22;8(1):4325. (2018).ISI=4.259 doi: 10.1038/s41598-018-22750-7.
Israel Y, Ezquer F, Quintanilla ME, Morales P, Ezquer M, Herrera-Marschitz M. (2017) Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking inRats. Alcohol Alcohol. Jan;52(1):1-4. (2017). doi: 10.1093/alcalc/agw068 ISI= 2.724
Israel Y, Karahanian E, Ezquer F, Morales P, Ezquer M, Rivera-Meza M, Herrera-Marschitz M, Quintanilla ME (2017) Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line. Front Behav Neurosci. 2017 Apr 4;11:57. doi: 10.3389/fnbeh.2017.00057. ISI = 3.104
Rivera-Meza M, Muñoz D, Jerez E, Quintanilla ME, Salinas-Luypaert C, Fernandez K, Karahanian E (2017) Fenofibrate Administration Reduces Alcohol and Saccharin Intake in Rats: Possible Effects at Peripheral and Central Levels. Front Behav Neurosci. 2017 Jul 14;11:133. doi: 10.3389/fnbeh.2017.00133. ISI = 3.138
Berríos-Cárcamo P, Quintanilla ME, Herrera-Marschitz M, Vasiliou V, Zapata-Torres G, Rivera-Meza M (2017) Racemic Salsolinol and its Enantiomers Act as Agonists of the μ-Opioid Receptor by Activating the Gi Protein-Adenylate Cyclase Pathway.ISI= 3.104 Front Behav Neurosci. Jan 23; 10:253. (2017) doi: 10.3389/fnbeh.2016.00253
Quintanilla ME*, Rivera-Meza M, Berríos-Cárcamo P, Cassels BK, Herrera-Marschitz M, Israel Y (2016) (R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake. Addict Biol. Nov;21(6):1063-1071. (2016). doi: 10.1111/adb.12268* Corresponding author. ISI = 5.578
Quintanilla ME*, Rivera-Meza M, Berríos-Cárcamo P, Salinas-Luypaert C, Herrera-Marschitz M, Israel Y (2016) Beyond the «First Hit»: Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation. Alcohol Clin Exp Res. 40(5):1044-51. (2016).*First autor. ISI = 3.183
Sapag A, Irrazábal T, Lobos-González L, Muñoz-Brauning CR, Quintanilla ME, Tampier L (2016) Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. Mol Ther Nucleic Acids. Jul 12;5(7):e335. (2016). ISI= 6.392 doi: 10.1038/mtna.2016.41
Karahanian E, Rivera-Meza M, Quintanilla ME, Muñoz D, Fernández K, Israel Y (2015) PPARα Agonists Reduce Alcohol Drinking: Do They Act in the Brain or in the Liver? Alcohol Alcohol. Nov;50(6):717-8. (2015). doi: 10.1093/alcalc/agv060 ISI= 2.724
Israel Y, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M (2015) The «first hit» toward alcohol reinforcement: role of ethanol metabolites.ISI= 2.829 Alcohol Clin Exp Res. May;39(5):776-86. (2015). doi: 10.1111/acer.12709.
Karahanian E, Rivera-Meza M, Tampier L, Quintanilla ME, Herrera-Marschitz M, Israel Y (2015) Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats. Addict Biol. Mar;20(2):336-44. (2015) doi: 10.1111/adb.12130. ISI= 4.603
Quintanilla ME*, Rivera-Meza M, Berríos-Cárcamo PA, Bustamante D, Buscaglia M, Morales P, Karahanian E, Herrera-Marschitz M, Israel Y (2014) Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. Alcohol. Sep;48(6):551-9. (2014) ISI = 2.425 * Corresponding author.
Karahanian E, Quintanilla ME, Fernandez K, Israel Y (2014) Fenofibrate–a lipid-lowering drug–reduces voluntary alcohol drinking in rats. Alcohol. Nov;48(7):665-70. (2014). doi: 10.1016/j.alcohol.2014.08.004. ISI= 2.391
Rivera-Meza M, Quintanilla ME, Bustamante D, Delgado R, Buscaglia M, Herrera-Marschitz M (2014) Overexpression of hyperpolarization-activated cyclic nucleotide-gated channels into the ventral tegmental area increases the rewarding effects of ethanol in UChB drinking rats. Alcohol Clin Exp Res. Apr;38(4):911-20. (2014) doi: 10.1111/acer.12344. ISI= 3.205